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FTO变异与减肥手术后的BMI, ghrelin 和大脑功能的变化有关
Guanya Li1,2, Yang Hu1,2, Wenchao Zhang1,2
1Center for Brain Imaging, School of Life Science and Technology, Xidian University and Engineering Research Center of Molecular and Neuroimaging, Ministry of Education, Xi'an, Shaanxi, China.
JCI insight
|August 1, 2024
概括
携带特定FTO基因变异的携带者在减肥手术后对食物线索和 ghrelin 信号产生改变的大脑反应,可能会阻碍长期减肥. 这种遗传变异影响神经敏感性和荷尔蒙调节,影响手术结果.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 腹部外科 腹部外科
背景情况:
- 脂肪质量和与肥胖相关的 (FTO) 基因中的一个常见的多态性与对食物线索的敏感性增加和减少胆固醇抑制有关.
- 与非携带者相比,具有风险等位基因的个体往往会在腹部外科手术后恢复更多的体重.
- 减肥手术后FTO变化的确切影响大脑功能和 ghrelin 水平仍在调查中.
研究的目的:
- 为了研究FTO基因变异对腹手术后大脑活动和 ghrelin 信号传递的影响.
- 探索FTO基因型,对食物线索的神经反应和长期体重管理结果之间的关系.
主要方法:
- 休息状态和暗示反应功能磁共振成像 (fMRI) 用于评估大脑功能对食物暗示的反应.
- 参与者包括rs9939609 A等位基因的载体 (AT) 和非载体 (TT).
- 在手术前和手术后的多个时间点 (1,6,12个月) 进行了脑部成像,行为评估长达5年.
主要成果:
- 与TT组相比,AT组在外科手术后显示出较少的BMI损失和后带状皮质静止状态活动减少.
- 携带者 (AT) 在背侧前额叶皮层 (DLPFC),背中前额叶皮层 (DMPFC) 和胰岛对食物线索的反应加剧.
- 在AT组中观察到体重减轻和格林水平之间的负相关性,在AT组中增加了DLPFC,DMPFC和insula激活,但不是TT组.
结论:
- FTO基因的变异影响了减肥手术后的 ghrelin 信号传递和大脑功能的动态.
- 与FTO基因型相关的神经处理和荷尔蒙反应的这些改变可能会阻碍成功的长期减肥.
- 了解这些遗传影响可以为减肥手术和体重管理提供个性化的方法.
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