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Updated: May 2, 2026

An HS-MRM Assay for the Quantification of Host-cell Proteins in Protein Biopharmaceuticals by Liquid Chromatography Ion Mobility QTOF Mass Spectrometry
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在应用程序中使用对反应性代谢物的结构警报SpotRMM

Alf Claesson1

  • 1Awametox AB, Lilldalsvägen 17 A, SE-14461 Rönninge, Sweden.

Chemical research in toxicology
|August 1, 2024
PubMed
概括

药物设计旨在防止反应性代谢物形成,这是造成肝损伤的原因. 许多具有肝毒性的激酶抑制剂显示结构性警报,但有些缺乏明确的警报,突出显示了当前药物安全性评估的局限性.

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