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Updated: Jun 18, 2025

Preparation of Extracellular Matrix Protein Fibers for Brillouin Spectroscopy

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Published on: September 15, 2016

使用Brillouin光散射测量血纵向粘度的诊断潜力

Jennifer Illibauer^1,2, Tamara Clodi-Seitz³, Alexander Zoufaly^3,4

¹Division of Anatomy, Center for Anatomy & Cell Biology, Medical University of Vienna, Vienna A-1090, Austria.

Proceedings of the National Academy of Sciences of the United States of America

|August 1, 2024

概括

布里卢因光散射 (BLS) 提供了一种快速的方法,可以使用最小的样本体积来测量等离子体粘度 (PV). 这种技术可以作为传统剪切粘度测量的代理,有助于疾病诊断.

科学领域:

生物物理学的生物物理.
医学诊断医学诊断医学诊断
类风病学类风病学类风病学

背景情况:

血粘度 (PV) 是各种疾病的关键生物标志物.
传统的光伏测量是耗时的,需要大量的样本.

研究的目的:

建立Brillouin光散射 (BLS) 作为测量纵向PV的方法.
为了证明BLS作为切割光伏测量的可行代理.
探索BLS用于诊断COVID-19等疾病.

主要方法:

利用了布里卢恩光散射 (BLS) 和角度分辨率光谱学.
从微升血体积测量纵向PV.
将BLS应用于健康人群和COVID-19患者的血中.

主要成果:

用BLS测量的纵向光伏有效地代表了传统的剪切光伏.
通过温度缩放,BLS提供了对等离子体成分和物理性质的洞察.
在COVID-19患者中,纵向粘度的增加与疾病严重程度相关.

结论:

BLS为光伏诊断提供了一种快速,低体积的方法.
高频纵向光伏及其温度缩放提供了有价值的诊断信息.
BLS有可能实施新的光伏诊断工具.

关键词:

布里卢因光散射的光散射.在 COVID-19 疫情中,血粘度血粘度血粘度纵向粘度纵向粘度纵向粘度

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Viscosity

Viscosity

When water is poured into a glass, it falls freely and quickly, whereas if honey or maple syrup is poured over a pancake, it flows slowly and sticks to the surface of the container. This difference in the flow of different kinds of liquids arises due to the fluid friction between the liquid layers and the liquid and the surrounding material. This property of fluids is called fluid viscosity. In this example, water has a lower viscosity than honey and maple syrup.
The SI unit of viscosity is...