酒精消费与残疾累积在多发性硬化症中的关联
Jing Wu1, Tomas Olsson1, Jan A Hillert1
1From the Institute of Environmental Medicine (J.W., L.A.); Department of Clinical Neuroscience (T.O., J.A.H., L.A., A.K.H.), Karolinska Institutet; and Centre for Occupational and Environmental Medicine (L.A.), Region Stockholm, Stockholm, Sweden.
Neurology(R) neuroimmunology & neuroinflammation
|August 1, 2024
概括
低至中度的酒精消费可能有利于多发性硬化症 (MS) 患者,特别是那些患有复发性复发性硬化症的患者.高酒精摄入量对疾病进展或生活质量没有显著影响.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 以前的研究表明,饮酒会影响多发性硬化症 (MS) 疾病的进展.
- 了解酒精的作用对于管理多发性硬化和患者的生活质量至关重要.
研究的目的:
- 调查酒精消费习惯对MS疾病进展的影响.
- 评估酒精摄入量对MS患者健康相关生活质量的影响.
主要方法:
- 利用2项基于人群的病例控制研究的数据,根据诊断时的酒精习惯对患者进行分类.
- 使用瑞典多发性硬化病登记册,对9051名多发性硬化病患者进行了长达15年的跟踪.
- 采用考克斯回归模型来分析残疾恶化 (EDSS) 和生活质量 (MSIS-29) 终点.
主要成果:
- 与非饮酒者相比,低和中度饮酒与不良扩展残疾状况表 (EDSS) 结果和身体恶化的风险降低相关.
- 这些好处主要在复发性缓解性多发性硬化症中观察到,在女性中更为明显.
- 高度饮酒并没有显著影响疾病进展;研究结果表明,逆因果偏差最小.
结论:
- 低至中度的酒精摄入量与复发性复发性多发性硬化症的更有利结果有关.
- 没有发现高酒精消费对MS疾病进展或结果有显著影响.
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