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相关概念视频

Exon Recombination02:32

Exon Recombination

3.6K
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon...
3.6K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

7.9K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
7.9K
Gene Conversion02:08

Gene Conversion

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Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
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Gene Duplication and Divergence02:37

Gene Duplication and Divergence

6.1K
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
6.1K
Gene Families01:57

Gene Families

8.8K
Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
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Recombinant DNA01:09

Recombinant DNA

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Overview
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相关实验视频

Updated: Jun 18, 2025

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
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A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

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一个新的基因.

Li Zhao1, Nicolas Svetec1, David J Begun2

  • 1Laboratory of Evolutionary Genetics and Genomics, The Rockefeller University, New York, NY, USA; email: lzhao@rockefeller.edu, nsvetec@rockefeller.edu.

Annual review of genetics
|August 1, 2024
PubMed
概括
此摘要是机器生成的。

新的基因可以从非基因序列中 de novo 产生,从而挑战了对基因重复的传统观点. 研究这些新型基因起源揭示了对基因组复杂性和进化的洞察力.

关键词:
适应性进化是适应性的进化.它们是de novo蛋白质.基因增加 基因增加基因损失是基因的损失.规范表达的表达方式.小型的ORF是小的ORF.

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De Novo Generation of Somatic Stem Cells by YAP/TAZ
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Novel Sequence Discovery by Subtractive Genomics
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Novel Sequence Discovery by Subtractive Genomics

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相关实验视频

Last Updated: Jun 18, 2025

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De Novo Generation of Somatic Stem Cells by YAP/TAZ
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科学领域:

  • 基因组学就是基因组学.
  • 进化生物学 进化生物学
  • 分子生物学分子生物学

背景情况:

  • 大多数新基因来自复制,但越来越多地认识到来自非基因序列的de novo起源.
  • 了解新基因的诞生对于完整的基因组进化图像至关重要.

研究的目的:

  • 审查关于新基因起源的研究进展.
  • 突出最近的进展,并确定该领域的挑战.
  • 概述未来研究的关键问题.

主要方法:

  • 关于新基因起源的研究的文献综述.
  • 分析最近的发现及其影响.
  • 识别技术和概念上的障碍.

主要成果:

  • 基因起源提供了对基因组复杂性的新见解.
  • 这些基因为研究基因功能和调节提供了独特的机会.
  • 研究发现了基因进化的意想不到的方面.

结论:

  • 新基因起源是一个重要的进化机制.
  • 需要进一步的研究来解决关键的挑战和问题.
  • 这一领域为基因组进化和基因出现提供了新的视角.