相关实验视频
Updated: Jun 18, 2025

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
怀孕期间接种 pertussis 疫苗的时间:证据和实施 - 一个系统的审查
Louise De Weerdt1, Sereina A Herzog2, Pierre Van Damme1
1Centre for the Evaluation of Vaccination, Vaccine & Infectious Diseases Institute, University of Antwerp, Antwerp, Belgium.
在第三季度早期对孕妇接种百日咳疫苗可以提供最佳的婴儿保护. 晚期接种疫苗可能会降低疫苗的有效性,强调需要一致的全球建议.
科学领域:
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
- 疫苗学 疫苗学 疫苗学
背景情况:
- 全球越来越多地采用孕产妇百日咳疫苗,以保护新生儿在脆弱的头几周内受到保护.
- 产前百日咳免疫接种的最佳时间仍然是正在进行的讨论和研究的主题.
研究的目的:
- 系统地审查关于母性百日咳疫苗接种安全性,免疫性和有效性的文献,以确定接种时间.
- 绘制全球关于怀孕期间百日咳疫苗接种的建议.
主要方法:
- 在PubMed,MEDLINE和Web of Science的系统文献综述.
- 包括45个关于安全性,免疫性和/或有效性的出版物.
- 对全球政府关于疫苗接种时间的建议进行分析.
主要成果:
- 没有发现与疫苗接种时间相关的安全问题增加.
- 第三个月初的疫苗接种似乎可以优化婴儿在出生时的免疫性.
- 与早期的疫苗接种相比,第三个月的晚期疫苗接种与疫苗有效性的降低有关.
结论:
- 在怀孕期间接种百日咳疫苗的时间显著影响婴儿免疫性和疫苗的有效性.
- 建议在第三季度早期进行疫苗接种,以最大限度地保护婴儿出生时.
- 全球各国的不同建议反映了关于最佳疫苗接种时间的不一致和有限的数据.
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