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肝细胞癌转移中的非编码RNA:显著的指标和潜在的致癌机制

Wenqi Qiu¹, Song Zhang², Wei Yu³

¹Department of Plastic and Aesthetic Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Computers in biology and medicine

|August 1, 2024

概括

非编码RNAs (ncRNAs) 通过调节主要信号通路中的关键基因,显著影响肝细胞癌 (HCC) 转移. 这些ncRNA显示出作为HCC的生物标志物和治疗点的潜力.

科学领域:

分子生物学分子生物学
在瘤学瘤学.
生物化学生化学

背景情况:

非编码RNAs (ncRNAs) 是细胞间过程的关键调节者,并且越来越多地涉及恶性瘤,特别是肝细胞癌 (HCC).
转移是HCC中复杂的过程,涉及多个信号通路.
了解ncRNAs在这些途径中的作用对于开发有效的治疗方法至关重要.

研究的目的:

综合审查ncRNAs在HCC转移机制中的多样性作用.
专注于ncRNAs在四个主要的HCC转移信号通路中的参与:Wnt/β-catenin,HIF-1α,IL-6和TGF-β.

主要方法:

文献综述和对ncRNAs和HCC转移现有研究的分析.
基于它们的调节机制 (DNA,RNA,蛋白相互作用) 的ncRNAs的分类.
专注于特定类型的ncRNAs:微RNAs (miRNAs),长非编码RNAs (lncRNAs) 和圆形RNAs (circRNAs).

主要成果:

ncRNAs,包括miRNAs,lncRNAs和circRNAs,在Wnt/β-catenin,HIF-1α,IL-6和TGF-β通路中的关键基因调节中发挥着重要作用.
这些ncRNAs利用不同的机制,例如与DNA相互作用以控制转录,RNA控制翻译,以及蛋白质控制稳定性.
ncRNAs 的失调有助于 HCC 的转移性进展.

结论:

ncRNAs通过它们对关键信号通路的调节,是HCC转移的关键参与者.
ncRNAs有可能成为HCC转移的诊断生物标志物.
ncRNAs代表了对抗HCC转移的有希望的治疗标.

关键词:

肝细胞癌是肝细胞癌.转移转移转移转移环绕RNAss 的时间.在 lncRNAs 中.这就是miRNAs.

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