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在肺状细胞癌中对DEL-1和与炎症相关的基因进行了基分析

Rahsan Ilikci-Sagkan¹, Dilara Fatma Akin², Recep Liman³

¹Uşak University, School of Medicine, Department of Medical Biology, Uşak, Türkiye.

|August 1, 2024

概括

这项研究揭示了DEL-1在肺状细胞癌 (LUSC) 发展中的重要作用. 在LUSC患者中观察到较低的DEL-1和IL-6水平,以及较高的CXCL13,这表明癌症进展的分子机制.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
基因组学就是基因组学.

背景情况:

肺状细胞癌 (LUSC) 占非小细胞肺癌 (NSCLC) 的20-30%,特别是在吸烟者中.
有限的研究存在于与LUSC相关的基因组和基因表达特征,特别是DEL-1,白细胞招募和促炎细胞因子之间的相互作用.

研究的目的:

在511名LUSC患者的队列中,研究关键基因的基因表达模式和突变概况,包括DEL-1和促炎细胞因子.
探索DEL-1表达与其他向基因之间的相关性,并进行生存分析.

主要方法:

在511名LUSC患者中,对目标基因 (DEL-1,TNF,IL-18,IL-1,CXCL8,CXCL13,IL-6) 的mRNA表达和突变概况的分析.
利用PolyPhen-2和SNAP程序来识别有害的突变.
进行基因表达分析和生存分析.

主要成果:

在目标基因中观察到总基因异常率为16.4%,在七种总突变中发现了两种致病突变.
发现了深度删除和基因放大.
与对照组相比,LUSC患者的DEL-1和IL-6表达水平明显较低,而CXCL13水平更高.

结论:

这项研究强调了DEL-1在LUSC病变发生过程中的重要作用.
这些发现表明,在癌症进展中涉及DEL-1的潜在分子机制.
这项in silico研究为未来在LUSC的实验研究提供了洞察力.

关键词:

德尔-1 是一个DEL-1.与炎症相关的基因在LUSC中使用LUSC.

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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...