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主要雷诺现象和继发于结缔组织疾病之间的临床相关差异

Stefano Di Donato¹, Suiyuan Huang², John D Pauling³

¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom.

Seminars in arthritis and rheumatism

|August 1, 2024

概括

主要雷诺现象 (PRP) 患者报告更多的疼痛和麻木,而次要雷诺现象 (SRP) 患者年龄较大,有更多的蓝色变化. 了解这些差异对于更好的RP管理至关重要.

科学领域:

血管医学血管医学
类风湿病学类风湿病学
患者报告的结果

背景情况:

雷诺现象 (RP) 涉及数字血管损害.
区分与连接组织疾病相关的初级RP (PRP) 和二级RP (SRP) 对于了解患者体验至关重要.

研究的目的:

调查患者体验中初级RP和二次RP之间的临床相关差异.
通过大规模的患者调查,探索RP的影响.

主要方法:

对雷诺现象 (PASRAP) 患者体验调查的横截面分析.
在线调查广泛传播,自愿和匿名参与.
1229名受访者自我报告RP (17.7%的PRP,82.3%的SRP).

主要成果:

SRP患者年龄较大 (54.2岁与41.7岁相比),并且更频繁地经历了蓝色变色 (92.2%与86.5%相比).
在PRP患者中,疼痛 (72.1%与55.9%相比),麻木 (80.3%与69.4%相比),刺痛/刺痛 (93.4%与80.8%相比) 和刺痛 (84.0%与77.5%) 的情况较多.
对一半的受访者来说,症状控制不足,在SRP中报告了更好的控制 (55.2%与45.2%相比).

结论:

在PRP和SRP患者的生活经历中存在临床上显著的差异.
在PRP中,神经感官症状更为普遍,而SRP与年龄较大,更多的色和较少的症状分辨率有关.
结果为设计未来RP临床试验提供了洞察力.

关键词:

临床试验中的临床试验.结合性组织疾病结合性组织疾病结果措施结果措施.主要是雷诺的病.雷诺的现象是雷诺的现象.脊髓硬化症是什么脊髓硬化症二次雷诺的雷诺的系统性硬化症系统性硬化症

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