放射治疗,免疫和免疫检查点抑制剂
Connor Lynch1, Sean P Pitroda2, Ralph R Weichselbaum2
1Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.
The Lancet. Oncology
|August 1, 2024
概括
放射治疗可以刺激或抑制免疫系统. 将放射治疗与免疫检查点抑制剂 (ICI) 结合起来是有希望的,但取得的成功有限,因此需要采取战略来克服放射治疗诱导的免疫抑制.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 辐射瘤学 辐射瘤学
背景情况:
- 放射治疗 (RT) 对免疫系统有双重影响,无论是在瘤微环境中的局部效应还是系统效应.
- 临床前研究表明RT和免疫检查点抑制剂 (ICI) 之间的协同作用,导致临床试验.
研究的目的:
- 审查RT的免疫刺激作用,这支着ICI的组合试验.
- 根据RT的免疫抑制作用,分析放射性免疫治疗的临床试验结果.
- 确定减轻RT诱导免疫抑制的策略,以提高治疗疗效.
主要方法:
- 对RT诱导免疫反应的临床前数据的文献综述.
- 对放射性免疫治疗发表的临床试验结果的分析.
- 检查RT诱导的免疫抑制背后的机制.
主要成果:
- 早期对放射性免疫治疗的乐观看法在临床试验中并不总是得到满足.
- 在治愈和转移的环境中,联合RT-ICI治疗的成功程度有限.
- 在组合疗法中,RT的免疫抑制作用可能会抵消其免疫刺激潜力.
结论:
- 克服放射治疗诱导的免疫抑制对于提高联合RT-ICI治疗的疗效至关重要.
- 针对免疫抑制途径可以释放放射性免疫治疗的全部潜力.
- 需要进一步的研究来优化组合策略,以获得更好的患者结果.
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