那不勒斯预后得分和肺部健康协会:一个基于人口的研究
1Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; West China School of Medicine, Sichuan University, Chengdu, China.
那不勒斯预后得分 (NPS) 与肺部健康状况恶化有关,包括慢性肺部疾病和呼吸系统症状的几率增加. 更高的NPS也预测肺部疾病患者的死亡风险更高.
科学领域:
- 肺部医学 肺部医学
- 炎症生物标志物 炎症生物标志物
- 公共卫生 公共卫生
背景情况:
- 那不勒斯预后分数 (NPS) 是一种新的炎症和营养状况指标.
- 它与肺部健康的关系在很大程度上仍未被探索.
研究的目的:
- 评估NPS与慢性肺部疾病之间的关联.
- 为了确定NPS对呼吸系统症状和肺功能的预测值.
主要方法:
- 来自国家健康和营养检查调查 (2007-2012) 的15600名参与者的分析.
- 使用血清白蛋白,总胆固醇和中性粒细胞对淋巴细胞和淋巴细胞对单细胞的比率计算NPS.
- 使用生存分析和回归模型评估与慢性肺病,呼吸系统症状,螺旋计和死亡率的关联.
主要成果:
- 较高的NPS得分与喘,慢性支气管炎和呼吸系统症状的可能性增加有关.
- 较高的NPS与阻塞性和限制性螺旋计模式的风险更高,FEV1和FVC的降低有关.
- 最高的NPS类别与明显更高的全因和慢性下呼吸道疾病死亡风险有关.
结论:
- 较高的那不勒斯预后分数与一系列不良的肺部结果有关.
- 需要进一步的前性研究来确定NPS作为肺部健康受损的可靠生物标志物.
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