拉斯库富洛克萨辛对人类肠道和唾液微生物群的时间效应:使用下一代测序方法分析
Kengo Mukuda1, Ryo Inoue2, Miyako Takata3
1Division of Infectious Diseases, Faculty of Medicine, Tottori University, Nishi-cho 86, Yonago, Tottori, 683-8503, Japan.
概括
拉斯库弗洛克萨 (LSFX) 对健康患者和肺炎患者的肠道和唾液微生物群多样性产生影响. 虽然丰富性和β多样性在28天内恢复,但唾液微生物群的均性可能不会完全恢复.
科学领域:
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
- 人类微生物组 人类微生物组
背景情况:
- 抗微生物治疗可以破坏人类微生物群.
- 新型诺基诺的拉斯库富洛克萨 (LSFX) 对人类微生物群的影响尚不清楚.
- 这项研究研究了LSFX对健康个体和肺炎患者的肠道和唾液微生物群的影响.
研究的目的:
- 评估拉斯库富洛克萨辛 (LSFX) 对肠道和唾液微生物群的影响.
- 为了比较LSFX对健康参与者和肺炎患者的影响.
- 评估LSFX管理后微生物群多样性和组成的恢复.
主要方法:
- 口服LSFX (75毫克/天) 给健康成年人和肺炎患者.
- 在五个时间点 (第0,3,7,14,28天) 采集便和唾液样本.
- 使用下一代测序对α和β多样性和细菌组成的分析.
主要成果:
- LSFX降低了肠道和唾液微生物群的α多样性,在健康个体的第3天的最低值.
- 肠道微生物丰富度 (Chao1) 在28日恢复;然而,均性 (Shannon) 没有完全恢复.
- 唾液微生物群多样性 (Chao1和Shannon) 在28天内没有恢复. 在第28天,Beta多样性恢复.
- 特定的细菌家族如Lachnospiraceae在肠道中减少,而Granulicatella,Streptococcus,Prevotella和其他细菌在唾液中减少.
结论:
- 拉斯库佛洛克萨 (LSFX) 对肠道和唾液微生物群的组成和多样性产生不同的影响.
- 微生物群丰富性和β多样性在LSFX给药后28天内恢复.
- 唾液微生物群的均性可能需要超过28天的更长的恢复期.
相关概念视频
01:50What is Monogastric Digestion?
71.0K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
71.0K
01:29Bacterial Flora of the Large Intestine
408
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
408