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一种基于分支的聚合物剂,通过磁共振成像技术高效精确地准纤维化疾病

Xiaoming Wang¹, Jie Chen², Zhiqian Li²

¹Department of Radiology, Huaxi MR Research Center (HMRRC), Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China; Department of Radiology, Chongqing General Hospital, No.118, Xingguang Avenue, Liangjiang New Area, Chongqing 401147, China.

Journal of controlled release : official journal of the Controlled Release Society

|August 1, 2024

概括

基于加多的新型聚合物POADGd和PODGd作为先进的磁共振成像 (MRI) 对比剂. POADGd专门针对纤维化,使肝脏和肺部疾病的准确,非侵入性诊断成为可能.

科学领域:

聚合物化学聚合物化学
生物医学成像技术生物医学成像技术
材料科学材料科学材料科学

背景情况:

纤维化检测通常依赖于侵入性方法,如活检.
目前的MRI对比剂在特异性和安全性方面存在局限性.
开发有针对性和可生物降解的对比剂对于改善诊断至关重要.

研究的目的:

合成和描述基于加多的新型高分支聚合物 (POADGd和PODGd) 用于基于MRI的纤维化检测.
评估它们作为MRI对比剂的性能,重点关注放松性,准能力和生物安全性.
为了证明POADGd在肝脏和肺纤维化的非侵入性诊断方面的潜力.

主要方法:

通过RAFT聚合,合成基于加多的高分支聚合物 (POADGd,PODGd).
聚合物属性的表征,包括放松性和生物相容性 (OEGMA).
在体外和体内评估准特异性 (POADGd与PODGd) 和纤维化模型中的MRI性能.

主要成果:

与临床DTPA-Gd (3.74 mM−1s−1) 相比,POADGd和PODGd的放松度显著更高 (9.81和9.58 mM−1s−1).
POADGd证明了在纤维化组织中对素的特定向,从而导致高空间分辨率和信号与噪声比.
使用POADGd的MRI结果与病理发现密切一致,提供一种非侵入性诊断替代方案.

结论:

POADGd和PODGd是有效的MRI对比剂,具有增强的放松性和生物降解性.
POADGd的特定准能力使得肝脏和肺纤维化的准确,非侵入性诊断成为可能.
POADGd显示出出色的生物安全性和低毒性,将其定位为临床应用的有希望的药物.

关键词:

艾利西因 (Allysine) 是一种类型的氨基酸.肝脏纤维化肝脏纤维化肺部纤维化肺部纤维化这就是为什么MRI是MRI.宏分子对比剂是一种巨分子对比剂.

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