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Updated: May 6, 2026

Mapping the Binding Site of an Aptamer on ATP Using MicroScale Thermophoresis
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Published on: January 7, 2017

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发现和设计一种能通过阻断Stx2 B亚单元-Gb3相互作用来抑制Shiga毒素2型活性的aptamer

Mengxia Duan1, Kexin Ren1, Xiaowan Chen1

  • 1State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.

International journal of biological macromolecules
|August 1, 2024
PubMed
概括

研究人员开发了体,以阻止Shiga毒素 (Stx) 进入细胞. 阿普塔默B2在细胞培养物中显著抑制了Stx2的毒性,并减少了小鼠的损伤,提供了一种控制食品传播危害的新方法.

关键词:
亚普特美尔 (Aptamer) 是一种药物.抑制抑制的抑制作用石加毒素是一种毒素.

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Inhibitors of Bacterial Protein Synthesis01:25

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Aminoglycosides constitute a highly potent class of bactericidal antibiotics that exert their antimicrobial effects by targeting the bacterial ribosome, specifically disrupting protein synthesis. These polycationic molecules consist of amino-modified sugars linked via glycosidic bonds to an aminocyclitol core such as 2-deoxystreptamine or streptamine. Their strong positive charges facilitate tight binding to the negatively charged phosphate backbone of ribosomal RNA (rRNA), primarily at the 16S...
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