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Updated: Jun 18, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
08:45

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Published on: July 17, 2020

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双价向结合生物PROTACs诱导致癌性SHP2的强烈降解

Megan Hoffman1, David Krum2, K Dane Wittrup3

  • 1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

The Journal of biological chemistry
|August 1, 2024
PubMed
概括

基于生物的向蛋白质降解 (bioPROTACs) 提供了一种新的方法来向像SHP2.2这样的难以实现的蛋白质. 双对应的招募增强了对抗癌症相关的SHP2突变的biopROTAC功效.

关键词:
这就是BioPROTAC.E3 无处不在的合酶这就是PROTAC.在 SHP2 中, SHP2 是 SHP2.SPOPOP SPOPOP 这是一个很大的问题.癌症 癌症 癌症 癌症 癌症蛋白质酶体蛋白质组是什么蛋白质降解 蛋白质降解蛋白质工程工程 蛋白质工程有针对性的蛋白质降解降解.

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