尿素-肌素比率和c-反应蛋白与COVID-19住院患者的营养风险之间的弱相关性:一个横截面研究
Jefferson S Souza1, Bruna M Giglio1, Patrícia C B Lobo1
1Faculty of Nutrition, Federal University of Goiás, Goiânia, Brazil.
Clinical nutrition ESPEN
|August 1, 2024
概括
这项研究发现,在住院COVID-19患者中,营养风险与尿素-肌素比率 (UCR) 和C反应蛋白 (CRP) 之间存在弱相关性. 营养风险很普遍,特别是在ICU,与UCR和CRP的联系很弱,在重症监护中,只有CRP在病房患者中.
科学领域:
- 传染性疾病 传染性疾病
- 临床营养学 临床营养学
- 生物化学 生物化学
背景情况:
- COVID-19显著影响营养和血液形成.
- 中性粒细胞-淋巴细胞比率 (NLR) 可以预测COVID-19的严重程度.
- 尿素-肌素比率 (UCR) 被探索为一种生物标志物,用于关键疾病的代谢.
研究的目的:
- 调查NLR,UCR,CRP和住院COVID-19患者的营养风险之间的关联.
- 评估NLR和UCR在COVID-19中的预后价值.
- 为了确定COVID-19中营养风险的潜在生物标志物.
主要方法:
- 对589名住院的COVID-19患者进行了回顾性横截面研究.
- 使用营养风险查评估的营养风险 (NRS, 2002).
- 使用标准生化方法量化NLR,UCR和CRP水平;统计分析包括曼·惠特尼U测试和二进制回归.
主要成果:
- 87.4%的患者有营养风险,其中91.9%在ICU.
- 患有NRS≥3的患者年龄较大,BMI较低,NLR和UCR较高,CRP较低.
- 在ICU患者中,营养风险 (NRS) 和UCR/CRP之间发现了微弱的关联,并且仅在病房患者中与CRP有关.
结论:
- 在ICU COVID-19患者中,营养风险和UCR/CRP之间存在弱相关性.
- 病房患者的营养风险显示出主要与CRP的弱相关性.
- 在这个COVID-19队列中,NLR和UCR可能不是营养风险的强有力的指标.
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