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Updated: Jun 18, 2025

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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预防性IL-23阻塞在双重CTLA-4和PD-1免疫疗法中将疗效和毒性分离

Mingyi Ju1,2, Jiaojiao Zhang1,2, Zhuoyuan Deng1,2

  • 1Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.

Journal for immunotherapy of cancer
|August 1, 2024
PubMed
概括

与免疫检查点抑制剂 (ICI) 相关的免疫相关不良事件 (irAEs) 发生的患者中,介质素-23 (IL-23) 的上调. 阻断IL-23可以预防irAEs,同时保持抗瘤疗效,提供一种管理ICI毒性的策略.

关键词:
这是自身免疫性疾病.生物标志物生物标志物细胞因子细胞因子免疫检查点抑制剂 免疫检查点抑制剂免疫相关不良事件 - irAEAE

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Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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