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相关概念视频

Flow Cytometry01:23

Flow Cytometry

12.6K
The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
In...
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Structure and Function of Platelets01:18

Structure and Function of Platelets

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
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相关实验视频

Updated: Jun 18, 2025

Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets
10:08

Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets

Published on: November 22, 2024

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流动细胞计和血小板检测

Andrew L Frelinger1

  • 1Center for Platelet Research Studies, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115-5737, USA.

Clinics in laboratory medicine
|August 1, 2024
PubMed
概括
此摘要是机器生成的。

流细胞计是诊断血小板疾病和评估血栓形成或出血风险的宝贵工具. 这种方法可以检测血小板激活的变化,即使在血小板数量低的患者中也是如此.

关键词:
血小板疾病 血小板疾病流动细胞计量流动细胞计量功能测试是指功能测试.现型化 (Phenotyping) 是一种表现方式.血小板 血小板 血小板 血小板 血小板血小板激活是指血小板激活.血小板减少症 (Thrombocytopenia) 是一个严重的疾病.

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Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
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Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

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Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
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Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells

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相关实验视频

Last Updated: Jun 18, 2025

Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets
10:08

Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets

Published on: November 22, 2024

477
Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

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Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
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Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells

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科学领域:

  • 血液学 血液学 血液学
  • 免疫学 免疫学 免疫学
  • 生物化学 生物化学

背景情况:

  • 血小板对于静血和血栓形成至关重要.
  • 血小板激活涉及显著的细胞变化.
  • 对血小板功能的临床评估对于诊断疾病和预测风险至关重要.

研究的目的:

  • 对血小板激活标记物的流动细胞计测试进行审查.
  • 突出流细胞计在血小板疾病诊断中的实用性.
  • 强调其在评估血栓形成和出血风险方面的作用.

主要方法:

  • 流细胞计用于检测血小板表面糖蛋白的变化.
  • 分析包括蛋白质表达和脂暴露的变化.
  • 这种方法适用于血小板数量低的样本.

主要成果:

  • 流细胞计有效地表征了血小板特异性疾病.
  • 它提供了一种衡量血栓形成或出血风险的方法.
  • 检测血小板激活标记物,如表面糖蛋白和脂的变化.

结论:

  • 流细胞计是一种多功能和敏感的技术,用于血小板功能分析.
  • 它在各种临床环境中提供诊断和预后价值.
  • 它的应用扩展到其他测试可能有限的患者.