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Updated: Jun 13, 2026

Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS
09:20

Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS

Published on: August 10, 2017

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探索基于化的HDAC8 PROTACs用于治疗血液恶性病和固体瘤

Chunlong Zhao1, Jianqiu Zhang1, Hangyu Zhou1

  • 1Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.

Journal of medicinal chemistry
|August 1, 2024
PubMed
概括

一种新的HDAC8 PROTAC,Z16,有效降解HDAC8并抑制癌细胞的增殖. 它对SMC3和基因素乙化有明显的影响,突出了其作为HDAC8功能的研究探针的潜力.

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High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines05:33

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

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