相关实验视频

Updated: May 6, 2026

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC

Published on: May 10, 2016

从体内验证到体内查的进展,用于评估白皮病诱导化学物质的危险性

Akira Tazaki¹, Delgama A S M Nishadhi², Ao Li²

¹Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan; Activities of the Institute of Innovation for Future Society of Nagoya University, Japan; Voluntary Body for International Healthcare in Universities, Nagoya, Aichi, Japan.

Environmental pollution (Barking, Essex : 1987)

|August 1, 2024

概括

一个新的危险评估系统准确地识别了导致白皮病的化学物质,一种皮肤脱色的情况. 该系统利用小鼠皮肤和黑色素细胞内质网膜应激作用,有助于预防环境诱导的皮肤疾病.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
皮肤病学皮肤病学

背景情况:

作为环境因素的化学品对人类健康构成风险.
暴露于罗多登醇 (RD) 引起了广泛的化学白皮病,突出了危险评估的必要性.
现有的数据确定了具有构成性或光敏感性白皮病诱导潜力的化学物质.

研究的目的:

开发可靠的危险评估系统,用于识别可诱导白皮病的化学品.
通过使用小鼠尾皮验证体内系统.
建立一种新的体外系统,用于评估构成性白皮病诱导功效.

主要方法:

利用以前开发的 in vivo 危险评估系统,使用小鼠尾皮.
研究了6种已知的白皮病诱导物和3种负对照.
开发了一种使用不朽化正常黑色素细胞的体外系统,以评估内质网膜 (ER) 应激诱导.

主要成果:

在体内系统正确识别了由阳性对照化学物质诱导的构成性白皮病,显示了黑色素和黑色素细胞的减少.
试验室系统根据ER应激诱导区分化学物质,而不是依赖于铁酶的细胞死亡或ROS产生.
该研究成功验证了一种体内工具,并提出了一种用于危险评估的新型体外工具.

结论:

鼠尾皮试验是一种强大的体内方法,用于确定构成性白血病诱导化学功效.
一个专注于黑色素细胞中ER应激的体外系统为评估白皮病诱导化学物质提供了一种方便的方法.
这项研究通过提供查系统来预防与环境有关的皮肤疾病,为环境学做出贡献.

关键词:

化学性白皮病化学性白皮病在ERER应力诱导过程中,应力诱导危险评估危险评估危险评估罗多德纳醇的使用方法尾部的皮肤尾部的皮肤

更多相关视频

The Lambda Select cII Mutation Detection System

The Lambda Select cII Mutation Detection System

Published on: April 26, 2018

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

相关概念视频

Mutagenicity and Carcinogenicity

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...

Toxicity Testing in Animals

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...