关节异型骨化动物模型:一个范围审查
1Department of Oral and Maxillofacial Surgery, Harvard School of Dental Medicine, Boston, MA, USA; Division of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA, USA.
International journal of oral and maxillofacial surgery
|August 1, 2024
概括
开发准确的关节异型骨化 (TMJ-HO) 的动物模型至关重要. 本综述综合了当前诱导动物TMJ-HO的方法,强调了研究这种疾病的挑战.
科学领域:
- 生物医学科学 生物医学科学
- 兽医医学 兽医医学 兽医医学
- 整形外科 整形外科 整形外科
背景情况:
- 关节异型骨化 (TMJ-HO) 是一种复杂的疾病,对其病变的理解有限.
- 对于TMJ-HO的现有动物模型有很大的差异,这给研究和临床翻译带来了挑战.
研究的目的:
- 对用于诱导TMJ-HO的现有动物模型进行范围审查.
- 识别和分类这些模型中使用的方法和条件.
- 突出当前研究中的差距,并建议未来的方向.
主要方法:
- 系统地搜索PubMed,科学网络和柯克兰图书馆数据库.
- 包括英语中详细介绍TMJ-HO诱导方法的体内研究.
- 排除了体外,人体,综述和书章研究.
主要成果:
- 二十四个出版物符合纳入标准.
- 通过手术,遗传或化学手段在各种物种 (绵羊,老鼠,老鼠,子,猪,山羊,狗,子) 中诱导HO.
- 模型与创伤性损伤,,关节炎,椎间盘穿孔,关节置换和骨折相关.
结论:
- TMJ-HO研究受到其多因子病因和不太了解的,特定物种的病原体的阻碍.
- 迫切需要更准确和可复制的动物模型,更好地反映人类TMJ-HO.
- 需要一个标准化的临床分类系统来推动未来的研究在这个领域.
相关概念视频
Bone Structure
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Classification of Bones
The bones of the human skeletal system are of varied shapes, sizes, and functions. They can be classified based on their shape and function into four major classes: long bones, short bones, flat bones, and irregular bones. Some classifications include a fifth type, the sesamoid bones, as a separate class, whereas others categorize them under short bones.
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The long...
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The long...


