相关实验视频
Updated: Jun 18, 2025

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Intralymphatic Immunotherapy and Vaccination in Mice
Published on: February 2, 2014
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利巴托® (Cemiplimab-rwlc) 是注射用于静脉注射的药物
Aditya K Gupta1,2, Avantika Mann3, Kimberly Vincent4
1Division of Dermatology, Department of Medicine, University of Toronto School of Medicine, Toronto, Ontario, Canada.
Skinmed
|August 1, 2024
概括
利比托亚 (cemiplimab-rwlc) 在晚期基底细胞癌 (BCC) 和皮肤状细胞癌 (CSCC) 中表现出抗瘤活性. 这种PD-1抑制剂已被批准用于这些晚期皮肤癌,证明了可接受的安全性.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 皮肤病学 皮肤病学
背景情况:
- 利比泰亚 (cemiplimab-rwlc) 是一种被编程死亡-1 (PD-1) 途径抑制剂.
- 利比泰亚 (Libtayo) 已获得FDA批准,用于晚期皮肤状细胞癌 (CSCC) 和最近用于晚期基底细胞癌 (BCC).
研究的目的:
- 评估塞米普利马布在患有晚期基础细胞癌 (BCC) 和皮肤状细胞癌 (CSCC) 的患者的疗效和安全性.
主要方法:
- 两个开放标签,单臂,第二阶段研究 (NCT03132636和NCT02760498) 调查了先进的BCC和CSCC中的塞米普利马布.
- 主要终点是通过独立的中央审查评估的客观反应率 (ORR).
主要成果:
- 在晚期BCC中,转移性BCC (mBCC) 的ORR为21%,局部晚期BCC (laBCC) 的ORR为31%.
- 在先进的CSCC中,ORR在不同的治疗臂和疾病阶段 (mCSCC和laCSCC) 范围从41%到49%.
- 塞米普利马布显示出可接受的安全性和抗瘤活性.
结论:
- 塞米普利马布在晚期BCC和CSCC患者中表现出显著的抗瘤活性和可接受的安全性概况.
- 推剂量为350毫克静脉注射每3周一次,用于先进的BCC和CSCC.
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