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探索血清氨基酸特征作为哈西莫托甲状腺炎患者的潜在生物标志物

Ebru Temiz^1,2, Sukru Akmese³, Ismail Koyuncu⁴

¹Department of Endocrinology, Diabetes and Nutrition Center, Université Catholique de Louvain, Brussels, Belgium.

Biomedical chromatography : BMC

|August 1, 2024

概括

哈西莫托甲状腺炎 (HT) 的发病因子尚不清楚. 代谢分析确定了六种血清氨基酸作为早期HT诊断的潜在生物标志物,有助于临床检测.

科学领域:

内分泌学在内分泌学.
免疫学免疫学免疫学
代谢学代谢学代谢学

背景情况:

哈西莫托甲状腺炎 (HT) 是一种自身免疫性疾病,其病因不明.
了解HT机制对于开发诊断工具至关重要.

研究的目的:

在患有哈西莫托甲状腺炎的患者中调查血清氨基酸概况.
通过代谢分析识别HT的潜在诊断生物标志物.

主要方法:

从30名HT患者和30名健康对照组的血清样本使用LC-MS/MS进行了分析.
统计分析发现了显著的氨基酸变化和途径改变.
接收器操作特征 (ROC) 曲线分析确定了生物标志物的性能.

主要成果:

在分析的32种血清氨基酸中,在27种血清氨基酸中观察到统计学意义上的变化 (p < 0.05).
六种氨基酸 (1-甲基希斯提丁,囊,诺瓦林,希斯提丁,谷氨酸和氨酸) 显示出高诊断准确度 (AUC > 0.98).
途径分析显示,氨酸,氨酸和氨酸的生物合成降解是显著影响的代谢途径 (p < 0.001).

结论:

血清氨基酸概况在患有和没有哈西莫托甲状腺炎的个体之间有显著差异.
五种特定的氨基酸显示为早期HT诊断的敏感和特定生物标志物具有前途.
代谢分析为HT病原和潜在的诊断策略提供了宝贵的见解.

关键词:

哈西莫托的甲状腺炎代谢分析师代谢分析师氨基酸剖析是指氨基酸的剖析.生物标志物生物标志物代谢过程中的代谢.

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