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Updated: Jun 18, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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双站点分子剂用于增强CDK12-DDB1复合体的蛋白质-蛋白质相互作用

Zemin Zhang1, Yuanqing Li2,3, Jie Yang4

  • 1The School of Pharmacy, Fujian Medical University, Fuzhou, China.

Nature communications
|August 1, 2024
PubMed
概括

研究人员开发了一种双站点分子,LL-K12-18,以稳定蛋白质-蛋白质相互作用 (PPI) 并增强循环K降解. 这种新方法通过抑制瘤细胞中的基因转录和增殖,显示出强大的抗癌效应.

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Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
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Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
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