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Updated: Jun 18, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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积极的全osteric调节的结构基础的metabotropic谷氨酸受体激活和内部化

Alexa Strauss1,2, Alberto J Gonzalez-Hernandez1, Joon Lee1

  • 1Department of Biochemistry, Weill Cornell Medicine, New York, NY, 10065, USA.

Nature communications
|August 1, 2024
PubMed
概括

积极的全调节剂 (PAMs) 激活和内化甲基酸盐受体 (mGluRs),独立地起作用或增强 Orthosteric 激动剂. 结构研究显示,PAMs重塑受体结构,影响信号通路.

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