遗传学和体力活动在代谢功能障碍的发病过程中的相互作用与肝脏疾病相关
Hanna Frostdahl1, Nouman Ahmad2, Ulf Hammar1
1Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Scientific reports
|August 1, 2024
概括
身体活动不会改变对肝脏脂肪或体积的遗传倾向. 较高的体力活动 (PA) 和肝脏特征的遗传风险似乎独立地起作用,无论遗传易感性如何,都有利于所有人.
科学领域:
- 遗传学 遗传学 是一个
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 遗传变异影响肝脏脂肪和体积,但身体活动 (PA) 在修改这些遗传影响中的作用尚不清楚.
- 了解基因与环境的相互作用对于个性化肝病预防策略至关重要.
研究的目的:
- 为了研究更高的体力活动 (PA) 是否会改变对肝脏脂肪和肝脏体积的遗传倾向.
- 检查遗传风险得分和PA与代谢功能障碍相关的肝病 (MASLD) 和慢性肝病 (CLD) 之间的相互作用.
主要方法:
- 利用了英国生物库数据,用于肝脂肪 (GRSLF) 和肝体积 (GRSLV) 的遗传风险评分 (GRS).
- 在超过24000名参与者中使用磁共振成像 (MRI) 评估肝脏脂肪和体积.
- 采用线性回归来分析GRS和自我报告的PA之间的相互作用,以确定肝脏特征和疾病诊断.
主要成果:
- 对于肝脂肪,GRSLF和PA之间没有发现显著的相互作用 (p相互作用 = 0.62).
- GRSLV和肝体积之间的关联没有受到PA水平的改变 (p相互作用 = 0.71).
- 帕没有改变对MASLD或CLD的遗传倾向.
结论:
- 身体活动和对肝脏脂肪和体积的遗传敏感性似乎独立运作.
- 无论是更高的PA还是遗传倾向,都会给肝脏健康带来好处,无论彼此如何.
- 这些发现表明,促进PA对所有人都是有益的,无论他们对肝脏特征的遗传风险概况如何.
相关概念视频
Overview of Lipid Metabolism
1.3K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.3K
Liver Physiology
477
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
477
Factors Affecting Drug Biotransformation: Biological
135
Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
135
Cell Specific Gene Expression
13.5K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
13.5K
Human Genetics
552
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
552
Inborn Errors of Metabolism
150
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
150


