营养不良与Sjögren综合征相关的间歇性肺病死亡率有关
Eunki Chung1,2, Ala Woo3, Seung Hyun Yong3
1Division of Pulmonology, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Republic of Korea.
营养状况显著影响Sjögren
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 临床营养学 临床营养学
背景情况:
- 在Sjögren综合征相关的间歇性肺病 (SjS-ILD) 中,营养状况的预后作用尚不清楚.
- 预后因素的早期识别对于管理SjS-ILD至关重要.
- 营养评估可能在SjS-ILD患者中提供预测价值.
研究的目的:
- 评估SjS-ILD患者的营养状况作为预后因素.
- 为了确定可靠的营养标志物来预测SjS-ILD预后.
- 评估营养状况对SjS-ILD死亡率的影响.
主要方法:
- 对112名SjS-ILD患者进行了回顾性观察研究.
- 用BMI,CONUT,GPS和预后营养指数 (PNI) 来评估营养状况.
- 用于预测预后的接收器操作特征 (ROC) 和卡普兰-梅尔分析.
主要成果:
- 预后营养指数 (PNI) 显示了最高的预测值 (最高的AUC).
- 一个PNI切线<47.7与显著增加的死亡率相关 (p=0.005).
- 多变量分析证实PNI<47.7作为增加死亡率的预测因素 (HR 9.40).
结论:
- 低预后营养指数 (PNI) 是SjS-ILD患者死亡率的重要预测指标.
- 对营养不良的早期营养干预对于改善SjS-ILD的结果至关重要.
- 在SjS-ILD管理中,PNI是风险分层的宝贵工具.
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