阿基里斯肌弹性图的预测能力对于老年人的脆弱性
Eda Ceker1, Ayse Fadiloglu2, Esra Cataltepe2
1Faculty of Medicine, Department of Geriatric Medicine, Gazi University, 06560, Ankara, Turkey. edaceker@gazi.edu.tr.
European geriatric medicine
|August 1, 2024
概括
阿基里斯肌剪切波弹性图 (AT-SWE) 可以帮助识别老年人的脆弱性. 较低的AT-SWE测量与脆弱性增加有关,这表明它作为客观评估工具的潜力.
科学领域:
- 老年学是指老年学的学科.
- 生物医学工程 生物医学工程
- 肌肉骨超声波 肌肉骨超声波
背景情况:
- 衰老过程会影响阿基里斯肌 (AT) 的弹性,阿基里斯肌是人体最大的肌.
- 在老年人中,AT硬度和脆弱性之间的关系尚未得到充分理解.
- 身体虚弱是老年人群的一个重大问题,影响健康结果.
研究的目的:
- 调查阿基里斯肌剪波弹性图 (AT-SWE) 的实用性,以评估老年人的身体脆弱性.
- 为了确定AT-SWE是否可以作为脆弱性的非侵入性标记.
- 探索AT刚性和脆弱表型之间的关联.
主要方法:
- 一项横截面研究包括148名65岁及以上的参与者.
- 排除标准包括心力衰竭,关节损伤,中风史,恶性瘤和关节障碍.
- 参与者接受了全面的老年和Fried脆弱性表型评估,通过超声波测量AT弹性图形.
主要成果:
- 30.4%的参与者被归类为脆弱.
- 脆弱的个体呈现出统计上较低的AT-SWE测量值 (p < 0.05).
- AT-SWE与脆弱性独立相关 (OR 0.982,p = 0.038) 的AUC为0.647.
结论:
- 作为老年人脆弱性评估的非侵入性和客观方法,AT-SWE显示出希望.
- 这种技术可能有助于早期识别和管理脆弱性.
- 进一步的研究可以验证AT-SWE在预测老年人的健康结果方面的作用.
相关概念视频
01:19The Effect of Aging on Tissues
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
01:00Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
01:26Aging
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...