[腹腔疾病中的性别医学]
1Departement of Surgery, Mater Misericordiae University Hospital, Dublin, Irland.
Chirurgie (Heidelberg, Germany)
|August 1, 2024
概括
恶性腹膜疾病,通常来自胃,卵巢或结直肠癌,在诊断和治疗方面存在挑战. 化疗副作用和生存率的性别特异性差异需要进一步调查,以获得公平的患者护理.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 癌症研究 癌症研究
背景情况:
- 恶性腹膜疾病很常见,但在癌症登记册中经常被低估.
- 腹膜转移常常是由胃,卵巢和结直肠癌引起的.
- 在全身化疗耐受性和毒性方面存在性别特异性差异.
研究的目的:
- 审查目前对腹腔疾病的理解,重点关注恶性疾病.
- 讨论治疗方式,包括细胞还原性手术和高热性腹腔内化学输液 (HIPEC).
- 突出发生率,治疗反应和不良事件的性别特异性差异.
主要方法:
- 审查关于腹腔疾病及其管理的现有文献.
- 对治疗结果和副作用的分析,注意性别特异性的变化.
- 考虑生育能力和更年期作为接受手术的年轻患者的关键方面.
主要成果:
- 腹转移很常见,但由于报告不一致,很难量化.
- 带有或没有HIPEC的细胞还原性手术是关键的手术选择,可能需要进行子宫切除/salpingo-oophorectomy.
- 妇女经历更多的化疗胃肠道和血液学副作用;生存率显示根据癌症类型和阶段的细微差别.
结论:
- 在腹癌发病率,治疗和结局方面观察到显著的性别特异性差异,但没有完全解释.
- 对年轻患者来说,保持生育能力和治疗阳性更年期是非常重要的考虑因素.
- 进一步的研究对于阐明性别差异的原因和优化所有患者的治疗至关重要.
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