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制备水溶性多离子复合体 (PIC) 菌丝与pH响应的碳基贝他因块

Kaito Yokota¹, Rintaro Takahashi², Vu Thi Ngan¹

¹Department of Applied Chemistry, Graduate School of Engineering, University of Hyogo, 2167 Shosha, Himeji, Hyogo, 671-2280, Japan.

Macromolecular rapid communications

|August 1, 2024

概括

新的双块共聚合物形成了pH响应的多离子复合体微粒. 这些小粒在酸性条件下自组,在pH 4以上解离,提供可调节的药物递送系统.

科学领域:

聚合物化学聚合物化学
材料科学材料科学材料科学
纳米技术纳米技术

背景情况:

诸如聚二甲基氧乙烯酸胆 (PMPC) 这样的基聚合物具有独特的特性.
碳氧贝他因 (PCBMA) 和阳离子聚合物 (PMPS) 可以表现出依赖pH的电荷行为.
像RAFT这样的受控聚合技术可以实现精确的共聚合物合成.

研究的目的:

为了合成双双和双双的双块共聚物.
为了研究聚离子复合体 (PIC) 微粒的形成和解离.
探索这些共聚合物的pH响应自我组装行为.

主要方法:

可逆添加-碎片化链转移 (RAFT) 聚合被用于共聚合物合成.
双块共聚合物M100C100 (PMPC-PCBMA) 和M100S100 (PMPC-PMPS) 的合成长度为100块.
在水溶液中研究了pH依赖的电荷行为和菌形成.

主要成果:

在中性pH下,M100C100表现出zwitterionic的行为,在酸性条件下表现出polycation的行为.
M100S100保持一个永久的阳离子电荷.
在酸性溶液中,M100C100和M100S100的混合物形成了球形的核心外PIC微粒,PMPC作为外.
由于PCBMA的deprotonation和静电相互作用的丧失,PIC微粒在pH 4以上解离.

结论:

响应pH的多离子复合体微粒可以从zwitterionic和anionic双块共聚合物中形成.
这些微粒的自我组装和拆卸是由pH诱导的电荷变化控制的.
这些发现表明了控制释放和纳米技术的潜在应用.

关键词:

卡尔博克西贝他因 (Carboxybetaine) 是一种控制的激素聚合.静电相互作用静电相互作用具有pH响应性的多离子复合体的复合体.

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