与生活方式相关的风险因素和背痛之间的关联:孟德尔随机化研究的系统审查和元分析
Jianbin Guan1, Tao Liu1, Ge Gao2
1Honghui-Hospital, Xi'an Jiaotong University, Xi'an, 710054, China.
BMC musculoskeletal disorders
|August 1, 2024
概括
诸如肥胖,失眠,吸烟和久坐不动等生活方式因素会导致背部疼痛的风险增加. 这一系统性审查和元分析证实了这些联系,为它们对背部疼痛发展的影响提供了有力的证据.
科学领域:
- 流行病学 流行病学
- 遗传学 遗传学是一种遗传学.
- 公共卫生 公共卫生
背景情况:
- 传统的观察性研究在确定生活方式因素和背部疼痛的因果关系方面存在局限性.
- 门德尔随机化 (MR) 提供了一个强大的方法来调查因果关系.
- 现有的关于背部疼痛的MR研究显示异质性,导致不清楚的因果估计.
研究的目的:
- 对生活方式因素和腰部疼痛进行系统审查和元分析.
- 为了澄清特定的生活方式因素和背部疼痛结果之间的因果关系.
主要方法:
- 一个PRISMA系统审查,结合孟德尔随机化 (MR) 研究.
- 对于每个生活方式因素,元分析综合了至少三项研究的数据.
- 研究的身体质量指数 (BMI),失眠,吸烟,饮酒,以及休时间的久坐行为.
- 评估了背部疼痛的结果,包括慢性疼痛,残疾和疼痛严重程度.
- 使用STROBE-MR指南评估研究质量.
主要成果:
- 从最初选的1576个中,包括了20个具有低偏差风险的高质量MR研究.
- 对于:BMI (OR 1.18 [1.08-1.30]),失眠 (OR 1.38 [1.10-1.74]),吸烟 (OR 1.30 [1.23-1.36]),酒精消费 (OR 1.31 [1.21-1.42]) 和休时间的久坐行为 (OR 1.52 [1.02-2.25]),发现了显著的积极因果作用.
结论:
- 生活方式因素包括BMI,失眠,吸烟,饮酒和久坐不动的行为与背痛有因果关系.
- 这些发现提供了强有力的证据,支持这些因素对背部疼痛发展的生物学贡献.
- 分析澄清了以前MR研究中异质性掩盖的因果关系.
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