肺癌手术后间歇性肺炎急性恶化的预测因素:一个多中心研究
Lijie Yin1, Rui Xu1, Xiaojian Liu1
1Department of Nuclear Medicine, China-Japan Friendship Hospital, Beijing, China.
BMC pulmonary medicine
|August 1, 2024
概括
手术前的2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) PET/CT发现,包括非癌症间歇性肺炎区域的SUVmax,结合间歇性肺病 (ILD) 的过程和D-Dimer水平,可以预测正在接受手术的肺癌患者的急性恶化 (AE).
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 肺部病理学 肺部病理学
背景情况:
- 间歇性肺病 (ILD) 的急性恶化 (AE) 是接受肺癌切除术的患者的重大外科风险.
- 确定AE的预测标志物对于改善这种高风险人群中的患者结果至关重要.
研究的目的:
- 评估手术前的2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) PET/CT发现与ILD肺癌患者中AE的发生之间的相关性.
- 在这个患者队列中确定术后AE的独立预测因子.
主要方法:
- 对210名接受切除的非小细胞肺癌患者的回顾性分析.
- 评估与AE相关的临床数据和F-FDG PET/CT发现.
- 多变量逻辑回归和ROC曲线分析以确定预测值.
主要成果:
- 48名患者 (22.8%) 患有ILD;9名 (18.75%) 患有AE.
- 对AE的独立预测因素包括ILD的过程,非癌性间歇性肺炎 (IP) 区域的SUVmax和D-Dimer水平.
- 与单独使用SUVmax相比,结合这三个因素显著改善了术后AE的预测 (AUC为0.963对比0.875).
结论:
- ILD过程,非癌性IP区域SUVmax和D-Dimer水平的组合为ILD肺癌患者的AE提供了高预测价值.
- 这种多标志物方法提高了识别患有术后AE风险的患者的能力.
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