甲基水平与潜伏结核病感染风险之间的显著关联:一个横截面研究
1Department of tuberculosis, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, No. 208, East Huan Cheng Road, Gongshu District, Hangzhou, 310000, Zhejiang, China.
BMC pulmonary medicine
|August 1, 2024
概括
甲基 (MeHg) 是潜在结核病感染 (LTBI) 的独立危险因素. 较高的MeHg水平,特别是超过5.75μg/L,显著增加LTBI风险,MeHg介导喘.
科学领域:
- 环境健康 环境健康
- 传染病流行病学 传染病流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 潜伏性结核病感染 (LTBI) 仍然是一个全球性的健康问题.
- 环境暴露,如甲基 (MeHg),正在越来越多地研究它们在传染病易感性方面的作用.
- 了解环境毒素和LTBI风险之间的相互作用对于公共卫生干预至关重要.
研究的目的:
- 调查血液中甲基 (MeHg) 水平与潜伏结核病感染 (LTBI) 风险之间的关联.
- 为了确定潜在的值效应和MeHg暴露与LTBI之间的独立关联.
- 探索MeHg在喘和LTBI之间的关系中的调解作用.
主要方法:
- 从NHANES 2011-2012数据集中对5243名参与者的横截面分析.
- 使用XGBoost和随机森林算法进行变量重要性排名.
- 使用受限立方线的关联分析,值效应分析和通用线性回归.
- 调解分析以评估MeHg在LTBI中的作用.
主要成果:
- 甲基 (MeHg) 被确定为与LTBI风险相关的最重要的变量.
- 观察到MeHg水平与LTBI风险之间存在显著的非线性关联 (P<0.05).
- 随着MeHg水平的增加,LTBI风险增加,在5.75μg/L以上观察到显著的关联 (P <0.05).
- 喘病史与MeHg水平有关,MeHg部分调解了喘和LTBI风险之间的关联.
结论:
- 甲基 (MeHg) 是潜在结核病感染 (LTBI) 的独立危险因素.
- 存在剂量与反应的关系,MeHg水平升高带来更大的风险.
- 在喘和LTBI之间的联系中,MeHg可能起着调解作用,这需要进一步调查.
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