一个系统的审查和贝叶斯分析的 dienogest 的不良影响
Rui-Rui Li1, Qing Xi2, Lei Tao2
1Department of Pharmacy, Aviation General Hospital of China Medical University, Beijing, 100012, P.R. China. liruirui0707@alu.scu.edu.cn.
BMC pharmacology & toxicology
|August 1, 2024
概括
迪恩奥杰斯特是治疗子宫内膜异位症和腺肌病的常见治疗方法. 大多数副作用都是轻微的,但可能会发生严重的不良事件,如骨密度下降.
科学领域:
- 妇科 妇科 妇科 妇科
- 药理学 药理学是指药理学的学科.
- 妇女健康 妇女健康
背景情况:
- 子宫内膜异位症和腺菌菌症显著影响妇女的健康.
- 迪恩诺杰斯特是治疗这些疾病的骨盆疼痛的第一线口服治疗,特别是对于那些不寻求立即怀孕的人来说.
研究的目的:
- 系统地审查和总结与二凝治疗相关的不良事件.
- 为了确定这些不良事件在患有子宫内膜异位症和腺肌病症的患者中的患病率.
主要方法:
- 对多个数据库 (PubMed,Embase,Cochrane Central,Clinicaltrials.gov) 和FAERS数据库进行系统审查.
- 搜索于2023年5月31日进行,使用与dienogest和不良反应相关的术语.
- 包括报告子宫内膜异位症或腺菌症治疗期间安全问题或不良反应的研究.
主要成果:
- 该审查包括39篇出版物,患者平均年龄为34.43岁,随访持续时间从3到60个月.
- 最常见的不良反应:异常的子宫出血 (55%),缺血 (17%) 和胀 (13%).
- 报告的严重不良反应包括腰椎骨矿物质密度 (BMD) 降低和抑郁症. 腹痛,腹,恶心,吐,背痛和贫血在审查和FAERS数据中都被注意到.
结论:
- 迪恩诺杰斯特在治疗子宫内膜异位症和腺肌病时通常是安全的,最常见的副作用是轻微的.
- 意识到潜在的严重不良反应,如下降的腰椎骨质量和出血性休克是很重要的.
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