线粒体DNA拷贝数和乳头甲状腺癌的风险
Materah Salem Alwehaidah1, Rana Al-Awadhi2, Moody Al Roomy2
1Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait University, Jabriyah City, Kuwait. matra.alweheda@ku.edu.kw.
BMC endocrine disorders
|August 1, 2024
概括
线粒体DNA (mtDNA) 拷贝数量的增加与乳头甲状腺癌 (PTC) 风险的增加有关. 更高的mtDNA水平可以作为预测PTC发展的潜在生物标志物.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- 线粒体DNA (mtDNA) 拷贝数与瘤进展和癌症发生有关.
- 调查乳头甲状腺癌 (PTC) 中的mtDNA复制数对于了解甲状腺癌的发展至关重要.
- 评估mtDNA拷贝数作为PTC风险的潜在生物标志物是有必要的.
研究的目的:
- 调查mtDNA复制号和PTC之间的关联.
- 为了评估与mtDNA拷贝数相关的PTC发展风险.
- 为了将临床病理特征与PTC患者的mtDNA拷贝数相关联.
主要方法:
- 从105个PTC组织和67个控制甲状腺组织中提取DNA.
- 使用定量PCR (qPCR) 技术来确定mtDNA拷贝数和氧化损伤.
- 进行了统计分析,包括ROC分析,以评估诊断潜力.
主要成果:
- 相对mtDNA拷贝数在PTC组织中明显高于对照组织 (p < 0.001).
- 具有较高mtDNA复制数的第三种动物的PTC风险显著增加 (p趋势<0.001).
- 在PTC组织中观察到高的mtDNA氧化损伤 (p < 0.001),mtDNA复制数z-scores在区分PTC中的AUC为77.7%.
结论:
- 增加mtDNA拷贝数在甲状腺癌发病过程中起着重要作用.
- mtDNA复制数增强可能作为预测PTC风险的潜在生物标志物.
- 建议进一步研究mtDNA在甲状腺癌发生中的作用.
相关概念视频
Animal Mitochondrial Genetics
7.5K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
7.5K
Comparing Copy Number Variations and SNPs
17.7K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
17.7K
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
Non-LTR Retrotransposons
11.4K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.4K
Non-nuclear Inheritance
21.5K
Most DNA resides in the nucleus of a cell. However, some organelles in the cell cytoplasm—such as chloroplasts and mitochondria—also have their own DNA. These organelles replicate their DNA independently of the nuclear DNA of the cell in which they reside. Non-nuclear inheritance describes the inheritance of genes from structures other than the nucleus.
21.5K


