关于非人类灵长类动物在药物和疫苗评估中对非病毒病毒的使用的最新情况
Marc-Antoine de La Vega1, Ara Xiii1, Shane Massey2
1Galveston National Laboratory, Department of Microbiology and Immunology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA.
Expert opinion on drug discovery
|August 2, 2024
概括
非人类灵长类动物 (NHPs) 对于评估filovirus药物至关重要,但有机体和in silico模型等伦理替代品正在推进. 目标是减少对NHP的依赖,同时确保药物的安全性和有效性.
科学领域:
- 病毒学 病毒学
- 药物发现 药物发现 药物发现
- 动物模型 动物模型
背景情况:
- 非人类灵长类动物 (NHPs) 是评估埃博拉病毒和菲洛病毒药物的黄金标准,因为它们对疾病的相关性.
- 伦理考虑和动物研究的3R需要开发替代NHP模型的替代方案.
- 新兴技术,如 in silico 模拟和有机体模型,为药物测试提供了有希望的基于人类的系统.
研究的目的:
- 审查现有的NHP模型用于filovirus研究.
- 在NHP模型中检查现有的关于filoviruses药物发现的文献.
- 讨论在菲洛病毒研究中向无动物替代品的过渡.
主要方法:
- 对filio病毒的NHP模型的文献综述.
- 在相应的NHP模型中分析药物发现研究.
- 讨论新兴的无动物技术 (in silico,有机体).
主要成果:
- 对于对filovirus疫苗和药物的后期评估,NHP模型仍然是必不可少的.
- 体和有机体模型显示出潜力,但仍处于早期发展阶段.
- 通过提高可复制性和发布负面数据,可以实现NHP使用的改进和减少.
结论:
- 需要逐步向无动物模型过渡,从改进的小型动物模型,先进的有机体和in silico预测开始.
- 目前,NHP模型对于确保针对细菌病毒的医疗对策的有效性和安全性至关重要.
- 对替代模型的持续研究和验证对于道德和高效的药物开发至关重要.
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