诺基诺和偶然发作的风险:一个比较的回顾性研究
Itai Gueta1,2,3, Hagith Yonath2,3,4,5, Ronen Fluss5
1Institute of Clinical Pharmacology and Toxicology, Sheba Medical Center, Tel Hashomer, Israel.
在住院患者中,诺基诺 (FQ) 相关发作的发生率很低. 使用FQ的发作风险并没有显著超过使用宏化物 (MA) 观察到的风险,为临床决策提供了有价值的见解.
科学领域:
- 药物监督 药物监督 药物监督
- 临床药理学 临床药理学
- 传染性疾病 传染性疾病
背景情况:
- 基诺 (FQ) 已被事地与发作有关.
- 在FQ和其他抗生素之间的发作风险的比较仍然不清楚.
研究的目的:
- 在住院患者中调查与诺基诺 (FQ) 使用相关的发作的发生率.
- 为了比较FQ和类 (MA) 之间的发作风险.
主要方法:
- 对接受FQ或MA治疗的住院患者进行了回顾性观察研究.
- 倾向性得分匹配和逆概率加权 (IPW) 用于比较分析.
- 纳兰乔尺度评估了FQ治疗和之间的因果关系.
主要成果:
- 整体发作发生率低 (0.06%与FQ,0.07%与MA).
- 反向概率权衡估计FQ组与MA组的发作概率比率 (OR) 为1.44 (95% CI 0.59-3.5).
- 因果关系评估表明,在9/33和24/33分别的患者中,FQ和发作之间存在可能或可能的联系.
结论:
- 在住院患者中,诺基诺相关发作的发生率很低.
- 与诺基诺相关的发作风险并没有明显超过宏类的风险.
- 这些发现有助于临床医生平衡诺基诺治疗的风险和益处.
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