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在儿科传染性胃肠炎中使用"生物制剂"的最新情况
Alicia Wampers1, Koen Huysentruyt1, Yvan Vandenplas1
1Vrije Universiteit Brussel (VUB), UZ Brussel, KidZ Health Castle, Brussels, Belgium.
Expert opinion on pharmacotherapy
|August 2, 2024
概括
某些益生菌和后生菌可以通过恢复肠道微生物群来减少急性胃肠炎 (AGE) 的持续时间和严重程度. 需要更多的标准化研究来证实有效性,特别是食品补充剂.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 急性胃肠炎 (AGE) 与胃肠道微生物组的破坏有关.
- 特定的益生菌菌株,包括Lacticaseibacillus rhamnosus和Limosilactobacillus reuteri,已证明在减少AGE症状方面具有有效性.
研究的目的:
- 审查当前关于益生菌,益生菌,共生菌和后生菌治疗急性胃肠炎的证据.
- 确定现有研究的局限性,并为未来的研究提出建议.
主要方法:
- 使用PubMed和CINAHL数据库进行了文献搜索.
- 总结了截至2021年出版的关键评论,并调查了AGE中各种"生物"的新证据.
主要成果:
- 后生物质药物由于产品稳定性的提高和新出现的疗效证据显示出有前途.
- 在AGE中的"生物制剂"的研究设计,终点和管理协议中存在显著的异质性,限制了最终的结论.
结论:
- 对于儿科AGE试验,需要标准化的核心结果集,以提高证据的一致性.
- 目前食品补充剂的监管格局,优先考虑安全性而不是疗效,需要在产品上市之前进行强大的临床试验 (RCT).
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