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Updated: Jun 18, 2025

Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase COX/SDH Double-labeling Histochemistry
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通过精密工具产生的正交对硫化物产生提供了对线粒体硫硫的洞察力

Suman Manna1, Ragini Agrawal2, Tarun Yadav3

  • 1Department of Chemistry, Indian Institute of Science Education and Research Pune, Pune, Maharashtra, 411008, India.

Angewandte Chemie (International ed. in English)
|August 2, 2024
PubMed
概括

线粒体硫硫 (MSS) 影响人类免疫缺陷病毒 (HIV-1) 潜伏期. 这项研究开发了操纵MSS的工具,揭示了它在病毒活性和宿主细胞过程中的作用.

关键词:
3 - 甲基酸硫转移酶艾滋病病毒-1 艾滋病病毒-1硫化是一种硫化.线粒体硫硫酸盐的硫.转毒生物学 转毒生物学

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Structure and Nomenclature of Thiols and Sulfides

Thiols and sulfides are sulfur analogs of alcohols and ethers, respectively, where the sulfur atom takes the place of the oxygen atom. Thus, thiols are generally represented as RSH, where R is an alkyl substituent and —SH is the functional group. On the other hand, in sulfides, the central sulfur atom is bonded to two hydrocarbon groups on either side. Depending upon the type of group, sulfides can be either symmetrical or asymmetrical. Both thiols and sulfides display a bent geometry,...
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Thiols are prepared using the hydrosulfide anion as a nucleophile in a nucleophilic substitution reaction with alkyl halides. For instance, bromobutane reacts with sodium hydrosulfide to give butanethiol.
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During the electron transport chain, electrons from NADH and FADH2 are first transferred to complexes I and II, respectively. These two complexes then transfer the electrons to ubiquinol, which carries them further to complex III. Complex III passes the electrons across the intermembrane space to Cyt c, which carries them further to complex IV. Complex IV donates electrons to oxygen and reduces it to water. As electrons pass through complexes I, III, and IV, the energy released aids the pumping...
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The mitochondrial cristae membrane is the primary site for the oxidative phosphorylation (OXPHOS) process of energy conversion mediated through respiratory complexes I to V. These complexes have been widely studied for decades, and it has been proven that they form supramolecular structures called respiratory supercomplexes (SC). These higher-order complexes may be crucial in maintaining the biochemical structure and improving the physiological activity of the individual complexes while...
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