在美国,α-klotho水平与患有COPD的成年人之间存在关联
1Department of Pulmonary and Critical Care Medicine, Jinhua Municipal Central Hospital, The Affiliated Jinhua Hospital, College of Medicine, Zhejiang University, Jinhua, China.
Frontiers in medicine
|August 2, 2024
概括
高水平的α-klotho蛋白与40岁以下成年人慢性阻塞性肺病 (COPD) 的风险降低有关. 然而,这种保护性关联在较高的α-klotho度下会逆转.
科学领域:
- 肺部医学 肺部医学
- 老年学是一门学科.
- 生物化学 生物化学
背景情况:
- 慢性阻塞性肺病 (COPD) 涉及炎症,肺功能下降和受伤.
- 抗衰老蛋白 klotho 具有抗炎和抗氧化特性.
- 克洛托在COPD病变发生过程中的具体作用尚不清楚.
研究的目的:
- 调查血清α-klotho水平与成年人中COPD发病率之间的关联.
- 探索不同度的α-klotho与COPD风险的相关性.
- 为了确定与COPD患者不同水平的α-klotho相关的临床特征.
主要方法:
- 来自2007-2012年NHANES的676名参与者 (403名COPD,273名非COPD) 的数据分析.
- 在COPD和非COPD组之间比较临床特征.
- 后勤回归和通用添加模型来评估α-klotho度和COPD风险之间的关系.
主要成果:
- 非COPD患者的α-klotho水平高于COPD患者 (p < 0.05).
- 较高的α-klotho水平 (Q2和Q3与Q1) 观察到较低的COPD风险,赔率比分别为0.73和0.58 (p < 0.001).
- 慢性肺炎的风险随着α-klotho升高至1500 pg/mL而降低,然后在更高度下增加. 最低α-klotho组 (Q1) 的COPD患者更有可能是目前的吸烟者,并且已改变了红细胞,肌素和白细胞水平.
结论:
- 增加的α-klotho水平与40岁以下个体的COPD风险降低以及α-klotho水平低于1,500 pg/mL的相关.
- 在α-klotho水平为1,500 pg/mL或更高时,COPD风险随着α-klotho度的上升而增加.
- 肺功能和血细胞计数在COPD患者中具有不同的α-klotho水平而有所不同.
相关概念视频
01:20COPD: Pathogenesis and Clinical Features
251
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
251
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
01:26COPD: Management Using Bronchodilators and Corticosteroids
193
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
193
01:22Chronic Obstructive Pulmonary Disease
1.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.2K
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.7K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.7K