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患有急性白血病的狗的神经表现

Filipa L S Lyseight¹, Charles Pittaway¹, Ruth Dennis²

¹Oncology Service, Dick White Referrals, Part of Linnaeus Veterinary Limited, Cambridgeshire, United Kingdom.

Frontiers in veterinary science

|August 2, 2024

概括

狗的神经症状可能表明急性白血病 (AL),一种罕见的癌症. 这项研究详细介绍了6只患有AL的神经系统缺陷的狗的发现,显示了特定的MRI和CSF变化.

科学领域:

兽医神经学兽医神经学
血液学血液学血液学
兽医瘤学兽医瘤学

背景情况:

狗的急性白血病 (AL) 是一种罕见的造血性瘤.
在AL的狗中经常报告神经系统异常,但详细描述有限.
了解神经系统的表现对于诊断狗的AL至关重要.

研究的目的:

描述患有急性白血病 (AL) 的狗的临床发现,其主要抱怨是神经症状.
为了将神经学检查结果与高级成像 (MRI) 和脑脊液 (CSF) 分析在患有AL的狗中相关联.
为了确定犬类急性白血病的神经表现的关键诊断指标.

主要方法:

追溯搜索一个私人转诊医院数据库,对那些被诊断患有AL的狗进行追溯搜索,这些狗提交了神经病学部门.
纳入标准:神经学缺陷和随后的AL诊断.
分析神经学检查结果,磁共振成像 (MRI) 研究和脑脊液 (CSF) 分析.

主要成果:

确定了6例与神经症状相关的犬类急性白血病病例.
在检查时,所有病例都表现出焦点神经解剖学定位 (大脑或脊髓).
核磁共振扫描显示了透性中枢神经系统 (CNS) 模式,异常的脑膜增强和骨髓信号变化. 脑脊液分析显示蛋白质增加和非特异性多细胞症,没有检测到恶性细胞.

结论:

狗的急性白血病可能会出现焦点神经系统缺陷.
典型的MRI发现包括中枢神经系统透和骨髓变化.
增加的CSF蛋白质与负细胞学观察到神经系统受影响的狗与AL.

关键词:

急性白血病的磁共振成像技术骨髓磁共振成像骨髓磁共振成像中枢神经系统白血病中枢神经系统白血病患有急性白血病的狗.兽医神经瘤学兽医神经瘤学

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