多囊卵巢综合征,功能障碍和高尿血症之间的关联:系统性审查和元分析
Nicolas Daniel Widjanarko1, Archie Fontana Iskandar2, Felicia Grizelda Suryatenggara1
1Pertamina Dumai Hospital, Dumai, Riau, Indonesia.
Journal of human reproductive sciences
|August 2, 2024
概括
多囊性卵巢综合征 (PCOS) 与女性尿酸水平较高有关. 功能 (eGFR和肌素) 没有显著差异,这表明尿酸可能有助于分层PCOS相关的病风险.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生殖医学 生殖医学
背景情况:
- 多囊性卵巢综合征 (PCOS) 是一种常见的妇科疾病,影响生育年龄的女性.
- PCOS与代谢异常有关,这些异常会影响功能,并导致高尿血.
- 鉴于PCOS中心脏代谢风险因素的高患病率,预计功能障碍增加.
研究的目的:
- 调查PCOS,功能受损和尿酸水平升高之间的潜在关联.
- 为临床医生提供一种工具,以分层分类患有PCOS的女性病风险.
- 用随时可用的功能参数进行风险评估.
主要方法:
- 系统审查遵循系统审查和元分析 (PRISMA) 2020年指南的首选报告项目.
- 在MEDLINE,ProQuest和EBSCOhost数据库中进行文献搜索 (1996-2022),包括13项研究.
- 评估血清尿酸,血清肌素和估计的球过率 (eGFR);使用纽卡斯尔-太华尺度进行质量评估;与审查主管进行元分析 5.4.4.
主要成果:
- 患有PCOS的女性的尿酸水平显著上升 (平均差异[MD]=0.70,95%CI[0.45-0.95],P<0.00001).
- 在PCOS患者和对照人群中,血清肌素水平在统计学上相似 (MD = 0.08,95% CI [-0.05-0.21],P = 0.22).
- 估计的淋巴膜过率 (eGFR) 也没有显著差异 (MD = 3.54,95% CI [-4.53-11.61],P = 0.39).
结论:
- 多囊性卵巢综合征与尿酸水平升高显著相关.
- 在PCOS患者和对照人群之间没有观察到eGFR或肌素的显著差异.
- 常规尿酸评估建议PCOS患者作为病风险分层的简单工具.
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