在患有便秘的老年人中,维生素B12生产细菌的代表性下降,具有脆弱性
Luqing Zhao1, Xin Deng1, Ning Ding1
1Digestive Disease Center, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China.
iScience
|August 2, 2024
概括
老年人的便秘和虚弱与肠道微生物组的变化有关. 特定的微生物生物标志物,包括用于维生素B12合成的生物标志物,可以区分脆弱和非脆弱的便秘个体.
科学领域:
- 微生物学 微生物学
- 老年病的医生 老年病的医生
- 胃肠病学 胃肠病学
背景情况:
- 便秘和虚弱是老年人常见的疾病.
- 这两种情况越来越多地与肠道微生物组 (肠道失生症) 的改变有关.
- 了解特定的微生物特征可能有助于区分临床表现.
研究的目的:
- 在有或没有虚弱的便秘老年人中识别不同的肠道微生物特征.
- 发现微生物生物标志物来区分这些群体.
- 探索观察到的微生物差异的功能影响,特别是关于营养合成.
主要方法:
- 从61名参与者收集了便样本,包括有便的老年人有脆弱性 (Constipation_F),没有便的老年人 (Constipation_NF) 和健康的对照人 (C).
- 进行了16S rRNA基因测序,以分析肠道微生物组成.
- 随机森林模型被用来识别微生物的差异性属作为生物标志物.
主要成果:
- 与"便秘_NF"和"C"组相比",便秘_F"组显示肠道微生物多样性显著减少.
- 生物标志物面板被确定以区分便秘_F与便秘_NF (14个属),便秘_F与C (8个属),便秘_NF与C (5个属).
- 在Constipation_F组中观察到维生素B12合成途径 (P381-PWY,PWY-5507) 和相关细菌 (Actinomyces,Akkermansia) 的丰度减少.
结论:
- 便秘老人的肠道微生物群组成存在实质性的差异,有和没有虚弱.
- 特定的细菌系,特别是那些参与维生素B12合成的细菌系,显示出作为诊断标记物的潜力.
- 这些发现凸显了向肠道微生物群的治疗潜力,用于治疗老年人便秘和虚弱.
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