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结石风湿-白血病疫苗可以为SARS-CoV-2交叉反应性T细胞提供原始免疫

Sara Alonso Fernandez¹, Hector F Pelaez-Prestel¹, Tara Fiyouzi¹

¹Department of Immunology & O2, Faculty of Medicine, Complutense University of Madrid, Ciudad Universitaria, Madrid, Spain.

Frontiers in immunology

|August 2, 2024

概括

破伤风-白血病疫苗可以启动与SARS-CoV-2交叉反应的T细胞. 这种原始化可能会影响对COVID-19的免疫反应,这表明现有疫苗在病毒免疫中可能发挥作用.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学
病毒学病毒学

背景情况:

脊髓灰质炎 (Td) 疫苗可能会诱导对SARS-CoV-2的交叉反应性免疫力.
调查Td疫苗对SARS-CoV-2的T细胞免疫力的主要能力对于了解COVID-19保护至关重要.

研究的目的:

为了确定白血病 (Td) 疫苗是否可以对SARS-CoV-2产生交叉反应性CD8+T细胞免疫力.
评估现有的T细胞召回对SARS-CoV-2表位的反应,可能与Td疫苗抗原交叉反应.

主要方法:

鉴定了SARS-CoV-2 CD8+ T细胞表位,其序列与Td抗原相似.
在合成池 (TDX) 中组装了25个交叉反应性表位.
在人类PBMC和小鼠模型中使用细胞内IFNγ染色和试验室原始T细胞的Td疫苗原始化对T细胞的评估T细胞反应.

主要成果:

现有的CD8+ T细胞召回对Spike和TDX池的反应在受试者中占主导地位.
用Td疫苗启动的天真CD8+T细胞对TDX池表现出强烈的,特定的反应,而不是其他SARS-CoV-2.
在小鼠中的Td免疫引发了T细胞与TDX池交叉反应.

结论:

破伤风-白血病疫苗可以为SARS-CoV-2交叉反应性T细胞提供原始细胞.
接种Td疫苗可能会塑造T细胞对SARS-CoV-2的反应,可能有助于COVID-19免疫力.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.T细胞的交叉反应性标志性标志性标志性标志性 - 二疫苗的毒素疫苗可以使用.

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