肝移植后的胆道狭窄与细胞巨乳病毒感染无关
Juliano Félix Castro1,2, Ana Cláudia Souza2, Antônio Márcio de Faria Andrade1,2
1Division of Hepatobiliary Surgery, Department of Surgery, School of Medicine of the Federal University of Minas Gerais, Belo Horizonte, Brazil.
Translational gastroenterology and hepatology
|August 2, 2024
概括
细胞巨乳病毒 (CMV) 感染并没有独立预测肝移植 (LT) 后胆道狭窄. 虽然单变量分析中CMV与胆道并发症相关,但在多变量分析中,只有高的MELD得分是显著的风险因素.
科学领域:
- 肝病学和移植外科手术
- 移植中的传染病.
- 胃肠病学 胃肠病学
背景情况:
- 肝移植 (LT) 是末期肝病的主要治疗方法.
- 胆道并发症 (BCs),特别是狭窄和,仍然是一个重要的挑战后LT.
- 之前的研究表明,细胞巨乳病毒 (CMV) 感染和移植后胆道狭窄之间存在潜在的联系.
研究的目的:
- 调查细胞巨乳病毒 (CMV) 感染与肝移植 (LT) 患者胆道狭窄的发展之间的关联.
- 为了确定在LT之后胆道狭窄的危险因素.
主要方法:
- 对175名在2011年至2017年期间接受LT的成年患者进行了回顾性研究.
- 患者从脑死亡的捐赠者获得了注射IGL-1溶液的移植体,并在移植后至少12个月内进行了随访.
- 细胞巨乳病毒 (CMV) 感染通过抗原血症诊断;胆道狭窄通过磁共振胆瘤学 (MRCP) 诊断.
主要成果:
- 胆道并发症 (BCs) 在12%的移植中发生,狭窄是最常见的 (9.1%).
- 在22.9%的患者中存在细胞巨乳病毒 (CMV) 感染.
- 单变量分析显示CMV感染和BCs/胆管狭窄之间存在相关性 (P=0.01/0.008);然而,多变量分析仅确定MELD得分>21作为独立的风险因素 (P=0.02/0.01).
结论:
- 在这个队列中,细胞巨乳病毒 (CMV) 感染并不是发展非解剖性移植后胆道狭窄的独立风险因素.
- 末期肝病模型 (MELD) 的高得分与LT后胆道并发症和狭窄症的风险增加有关.
相关概念视频
01:26Diseases of the Liver and Gallbladder
499
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
499
01:17Chronic Bowel Disorders: Introduction
436
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
436