在肝硬化中的真菌感染
Humzah Iqbal1, Bilal Fazal Mehmood1, Katherine Jones1
1Department of Internal Medicine, University of California San Francisco, Fresno, CA, USA.
Translational gastroenterology and hepatology
|August 2, 2024
概括
肝硬化患者经历免疫功能障碍,增加严重真菌感染的风险. 本综述详细介绍了常见的真菌病原体,诊断挑战以及肝硬化患者这些感染的管理策略.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 肝硬化导致免疫功能障碍,增加细菌和真菌感染的风险.
- 虽然细菌感染有记录,但肝硬化患者的真菌感染却不太了解.
- 常见的真菌病原体包括Candida和Aspergillus,但像Coccidioides和Pneumocystis这样的新兴病原体正在增加.
研究的目的:
- 探索晚期肝病中的免疫功能障碍机制.
- 审查肝硬化患者真菌感染的流行病学.
- 讨论该群体中真菌感染的临床表现,诊断和管理.
主要方法:
- 文献综述侧重于免疫功能障碍,真菌流行病学和肝硬化病的临床管理.
- 诊断工具的分析,包括血清标记物 (β-D-葡萄糖,银河),培养物和成像.
- 考虑进行支气管镜检查,支气管膜洗 (BAL) 和肺部活检.
主要成果:
- 肝硬化患者的免疫功能障碍使其易患入侵性真菌感染 (IFI).
- 诊断是具有挑战性的,需要区分殖民和侵入性疾病.
- 血清标记,培养和成像对于诊断至关重要.
结论:
- 侵入性真菌感染是肝硬化的一个重要问题,影响患者的治疗结果.
- 及时诊断和适当的抗真菌治疗是必不可少的.
- 了解真菌感染对于管理肝病和肝移植资格至关重要.
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