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RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
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非编码的圆形RNAcircHomer1调节了小鼠视觉皮层中的突触发育和经验依赖的可塑性.

Kyle R Jenks1,2, Ying Cai3,2, Marvin Eduarte Nayan4,2

  • 1Department of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA.

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概括

循环RNAs (circRNAs) 调节大脑的可塑性. 这项研究表明,circHomer1对小鼠视觉皮层发育和经验依赖的突触可塑性至关重要.

关键词:
圆形的RNARNA是一个圆形的RNA.关键时期关键时期.经验依赖的可塑性是经验依赖的.眼睛主导性的可塑性 眼睛主导性的可塑性主要视觉皮层的主要视觉皮层.突触性可塑性 突触性可塑性

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科学领域:

  • 神经科学是一个神经科学.
  • 分子生物学分子生物学
  • 遗传学 遗传学 是一个

背景情况:

  • 循环RNAs (circRNAs) 在大脑中丰富,但它们在经验依赖可塑性中的功能在很大程度上是未知的.
  • 突触可塑性对学习和记忆至关重要,涉及经验影响的神经元连接的变化.

研究的目的:

  • 为了研究circRNAs在小鼠视觉皮层的经验依赖可塑性中的作用.
  • 为了确定由单眼剥夺 (MD) 调节的特定circRNA,并阐明它们的功能.

主要方法:

  • 在3天单眼剥夺 (MD) 后,在小鼠视觉皮层中对mRNA和circRNA表达的全转录组分析.
  • 使用分子技术对circHomer1进行淘汰.
  • 视觉反应,树突脊柱形态和AMPA受体动态的评估.

主要成果:

  • MD改变了多个circRNAs的表达,包括circHomer1,它增加了,而Homer1a减少了.
  • circHomer1 knockdown 降低了视觉可塑性,减少了树突脊柱大小,并阻止了 AMPA 接收器表面的减少.
  • circHomer1 knockdown 抑制了AMPA受体的经验依赖性内细胞分裂.

结论:

  • 在发育中的大脑中,circRNAs是由经验依赖的可塑性调节的.
  • circHomer1在视觉皮层突触发育和可塑性中发挥着关键作用,特别是在调节AMPA受体贩运方面.