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Updated: Jun 18, 2025

Functional Reconstitution and Channel Activity Measurements of Purified Wildtype and Mutant CFTR Protein
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Published on: March 9, 2015

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核糖体框架转移选择性调节错误折叠的CFTR变体的组装,功能和药物救援

Patrick Carmody1, Francis J Roushar1, Austin Tedman2

  • 1Department of Chemistry, Indiana University Bloomington, Bloomington, IN, USA 47401.

bioRxiv : the preprint server for biology
|August 2, 2024
PubMed
概括

在囊性纤维化转膜导电调节器 (CFTR) mRNA中新发现的一种RNA结构导致了核糖体框架转移. 这影响了 ΔF508 CFTR 蛋白组合,功能和药物救援,揭示了配翻译错折和翻译调节之间的联系.

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