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Updated: Jun 18, 2025

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SGLT2 抑制剂在人类心脏中激活泛酸激酶

Nicholas Forelli1, Deborah Eaton1, Jiten Patel1

  • 1Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

bioRxiv : the preprint server for biology
|August 2, 2024
PubMed
概括

糖共传输体-2 抑制剂 (SGLT2i) 激活泛酸激酶1 (PANK1),促进协酶A (CoA) 的合成. 这提高了心脏的燃料消耗,解释了SGLT2i在心力衰竭治疗中的好处.

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