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相关概念视频

Nucleic Acid Structure01:25

Nucleic Acid Structure

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
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Next-generation Sequencing03:00

Next-generation Sequencing

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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
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The Replisome03:01

The Replisome

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DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with...
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Nucleic acids02:43

Nucleic acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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PCR01:32

PCR

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Overview
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Nucleic Acids02:43

Nucleic Acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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相关实验视频

Updated: Jun 18, 2025

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
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DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

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序列可编程的核酸协同化物

Sumit Majumder1, Sebastian Coupe2, Nikta Fakhri3

  • 1Whitehead Institute for Biomedical Research, Cambridge 02142, USA.

bioRxiv : the preprint server for biology
|August 2, 2024
PubMed
概括
此摘要是机器生成的。

研究人员创建了可编程的DNA和RNA液体,其中分子相互作用控制材料特性. 这种自组装平台提供了关于细胞液体类隔间和可编程流体开发的见解.

关键词:
的DNA/RNA纳米技术.有关聚合物的聚合物.生物分子凝聚剂是生物分子的凝聚物.复杂的协动物液态-液态相隔离方法 液态相隔离方法可编程材料是可以编程的.

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Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
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Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
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科学领域:

  • 生物材料科学是生物材料的科学.
  • 分子生物学分子生物学
  • 软物质物理学 软物质物理学

背景情况:

  • 大自然采用复杂结构的自我组装,但将分子相互作用与宏观性质联系起来具有挑战性.
  • 弥合分子和宏观尺度需要具有可调节性质的模型系统.

研究的目的:

  • 设计可编程的DNA和RNA液体,具有可控制的材料特性.
  • 研究分子杂交如何影响这些核酸凝聚物的宏观性质.

主要方法:

  • 负电荷的DNA和RNA与聚酸的凝结形成类似液体的状态.
  • 使用序列特异性杂交来在液相内交叉链接核酸分子.
  • 测量分子扩散性和材料粘度,以与杂交能量相关联.

主要成果:

  • 成功生成了具有可编程材料特性的DNA和RNA液体.
  • 已经证明,分子间杂交可以使分子交叉连接,减少链动力学,并减缓分子扩散.
  • 像粘度和扩散度这样的宏观性质通过通过序列设计控制杂交能量来精确调节.

结论:

  • 核酸液体为创建自组装可编程流体提供了强大的平台.
  • 这项研究证明了对材料属性的基于序列的控制,弥合了分子相互作用和宏观行为.
  • 这项工作可能会增强对细胞内类似液体的区间的理解,并为新生物材料的设计提供信息.